中国地方病防治杂志

1996, (01) 28-30+72

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过量氟和硒对大鼠垂体、甲状腺、甲状旁腺的影响
EFFECT OF HICH FLUORINE AND SELENIUM ON PITUITARY GLAND, THYROID AND PARATHYROID IN THE RATS

卢传华,边建朝,叶平,咸树梅,刘源,纪庆宪

摘要:

为观察过量氟对大鼠垂体、甲状腺、甲状旁腺的影响及硒的保护作用,选用Wistar大鼠饮用30mg/L(1.58mmol/L)与50mg/L(2.63mmol/L)高氟水,同时设高氟水加富硒(se含量2.024mg/kg)饲料组。自实验第4个月光镜下见甲状腺呈现弥漫增生性改变,8个月和14个月出现增生和过度复原并存;垂体4个月光镜下尚无变化,8个月开始出现窦样毛细管增生并扩张充血,嗜酸性细胞变大增多,呈现分化和功能活跃表现;甲状旁腺光镜下自8个月开始见到旁腺增生、主细胞大小及数量增加等机能亢进表现。结果说明,氟中毒对垂体、甲状腺及甲状旁腺的损害是肯定的。本实验还观察到,硒有排氟作用,但未发现对垂体、甲状腺有显著的保护作用。

关键词: 氟中毒;硒;垂体;甲状腺;甲状旁腺

Abstract: In order to observe the effect of high fluorine (F)and the protection of selenium(Se)on pituitary gland,thyroid and parathyroid,wistar rat of 2 groups with chronic fluorosis were duplicated with 2 concentration F in the drinking water (1. 58,2. 63 mmol/L)and 2 groups were fed with Se fodders (2. 024mg/kg)and high F for 14 months. The results showed that in thyroid of optic microscope,there were pathological changes of wide-spread proliferation for 4 months and coexistence of proliferation and excessive rehabilitation for 8 and 14 months. Pituitary gland gave rise to the changes of the proliferation and the expansion in capillary, increase of quantity and size in acidophilic cells. At the same time,the proliferation and ascent of chief cells,of parathyroid gland were observed for 8 months. This suggested that(1)high F could damage these organs. (2)Se could antagonize high F but could not protect the organs of the rats with fluorosis.

Keywords: The rats with fluorosis;Se;Pituitary gland ;Thyroid ;Parathyroid

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